3 edition of Chemical Genetics and Chemical Genomics (Chapman & Hall/ CRC Mathematical Biology & Medicine) found in the catalog.
Chemical Genetics and Chemical Genomics (Chapman & Hall/ CRC Mathematical Biology & Medicine)
X. F. Steven Zheng
June 26, 2009
Written in English
|The Physical Object|
|Number of Pages||506|
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes Register to download data compounds against Mycobacterium tuberculosis hypomorphs and wild-type! New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of . Welcome to the chemical genomics website. This website provides an interface for querying the chemical genomics data. Valid queries include compound names (Benomyl), gene names (TUB3) or ORFs (YMLC), and Gene Ontology terms (tubulin complex assembly) or .
Chemical genetics is the study of biological systems using small molecule (‘chemical’) intervention, instead of only genetic intervention. Cell-permeable and selective small molecules can be used to perturb protein function rapidly, reversibly and conditionally with temporal and quantitative control in any biological system. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treatments. Systematic mapping of genetic networks by high-throughput chemical-genetic screens have given extensive insight in connections between genetic .
Clinical Genomics provides an overview of the various next-generation sequencing (NGS) technologies that are currently used in clinical diagnostic laboratories. It presents key bioinformatic challenges and the solutions that must be addressed by clinical genomicists and genomic pathologists, such as specific pipelines for identification of the full range of variants that are clinically important. Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes (∼80%) has no obvious phenotypic consequence in rich medium, it is difficult to study their functions. To uncover phenotypes for this nonessential fraction of the genome, we performed chemical genomic assays on the yeast whole-genome heterozygous Cited by:
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"[This book] is the first book dedicated solely to chemical genomics. It presents the most important research and developments in chemical genomics The plentiful tables and figures are well-designed and effectively support the content. highly recommended for academic and special libraries with relevant programs, and for research Format: Hardcover.
Advances in chemistry, biology, and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical : Hardcover.
In Chemical Genomics: Reviews and Protocols, leading edge researchers introduce the uninitiated into the various "flavors" of chemical genomics and describe a series of readily reproducible techniques for applications in organic chemistry, protein chemistry, and computer science, with emphasis on the high-throughput approaches that are the.
Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods Chemical Genetics and Chemical Genomics book study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological Book Edition: 1.
Chemical Genetics Piers Gaffney RoomRSC1, Department of Chemistry, Imperial College of Science and Technology and Medicine, Exhibition Road, London SW7 2AZ, UK.
This volume discusses easy-to-follow protocols for researchers in the field of plant chemical genomics. The chapters in this book look at technical workflows of high-throughput chemical compound screens in numerous plant tissues, such as seedlings, roots, and pollen.
Chemical genetics is the study of biological systems using small molecule (‘chemical’) intervention, instead of only genetic intervention. Cell-permeable and selective small molecules can be used to perturb protein function rapidly, reversibly and conditionally with temporal and quantitative control in any biological system.
This tutorial review has been written to introduce this emerging field to a broad audience and focuses later on areas of biology Cited by: The foundations of chemical genetics are firmly rooted in genetics, biochemistry and natural product research, and the field has evolved by incorporating functional genomics and Cited by: Introduction.
Chemical genomics technology has been steadily improving, delivering new biological probes and drugs, and the explicit use of the term ‘chemical proteomics’ has increased with it, as proteins have always been at the heart of this technology.
In Chemical Genomics and Proteomics: Reviews and Protocols, experts in the field present updated reviews of the chemistry of small molecules and their.
Plant Chemical Genomics: Methods and Protocols, expert researchers in the field detail many of the techniques used for identification of bioactive compounds from a large selection of fields in plant biology including plant pathogenesis, immune responses, small RNA processing, endomembrane trafficking, lipids, plant hormone signaling and cell wall.
This volume discusses easy-to-follow protocols for researchers in the field of plant chemical genomics. The chapters in this book look at technical workflows of high-throughput chemical compound screens in numerous plant tissues, such as seedlings, roots, Author: Friedrich Fauser.
Use of Chemical Genomics to Investigate the Mechanism of Action for Inhibitory Bioactive Natural Compounds. , DOI: /ch2. Mario Serrano, Erich Kombrink, Christian Meesters. Considerations for designing chemical screening strategies in plant biology. Chemical genetics is the study of biological systems using small molecule ('chemical') intervention, instead of only genetic intervention.
Cell-permeable and selective small molecules can be used Author: David R Spring. Chemical genomics and chemical genetics are often used interchangeably in al genomics is a broader umbrella term describing different types of large-scale in vivo approaches used in drug discovery, including chemical genetics but also large-scale screening of compound libraries for bioactivity against a specific cellular target/ by: 8.
Just as genetics offers a way to study biology by modulating gene function through mutation, chemical genetics seeks to study biology by modulating protein function with small molecules. As a much-cited historical example, the drug colchicine was used in early studies of mitosis to identify the protein tubulin .Cited by: Chemical genomics is a newly emerged and rapidly progressing field in biology, where small chemical molecules bind specifically and reversibly to protein(s) to modulate their function(s), leading.
Chemical genetics is a powerful new discipline in plant science. Bioactive small molecules can be used to identify novel signalling nodes and unravel redundant networks. Observations made so far have revealed a series of principles in plant chemical genetics. These principles concern compound properties, such as bioactivation and bioavailability; and valuable approaches, like the use of Cited by: Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae.
Here, we use yeast as a Author: Fu lai Zhou, Sheena C. Li, Yue Zhu, Wan jing Guo, Li jun Shao, Justin Nelson, Scott Simpkins, De hua. Chemical genetics/genomics. Genetic mapping, either linkage analysis or association, has been used widely to identify genetic loci or mutations that contribute to biologic traits or phenotypic variations .For genetic mapping, differences in phenotype are first identified from study populations or progeny of a genetic Cited by: 3.
Chemical genetics. Chemical genetics is a powerful new discipline in plant science. Bioactive small molecules can be used to identify novel signaling pathways and unravel redundant networks. Small molecules are used to alter protein function and explore biological roles of these target proteins.
A new field of science, chemical biology/ chemical genetics/ chemical genomics (cb/cg/cg) has emerged since the late 's, especially in the United States.
The NIH Roadmap agenda, Molecular Libraries Screening Center Network (MLSCN), became a drive force to push cb/cg/cg by: 5.Chemical Genomics Medicinal and Analytical Chemistry High-Throughput Screening.Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics.
This edited text, with contributions from experts in the field, discusses the new techniques and.